Triggers for Severe Depression:

1. Stressful Life Events: Major life changes such as the loss of a loved one, divorce, job loss, or financial problems.
2. Medical Conditions: Chronic illnesses like diabetes, heart disease, or chronic pain conditions.
3. Substance Abuse: Alcohol and drug abuse can both trigger and exacerbate depressive episodes.
4. Medications: Certain medications have side effects that may contribute to depression.
5. Lack of Sleep: Poor sleep patterns or insomnia can significantly affect mood and mental health.
6. Social Isolation: Lack of social support and feelings of loneliness can lead to depression.

Triggers for Acute Manic Episodes:

1. High Stress Levels: Significant stressors such as work pressure or personal conflicts.
2. Sleep Deprivation: Lack of sleep is a well-known trigger for mania in individuals with bipolar disorder.
3. Substance Abuse: Use of drugs like cocaine or amphetamines can induce manic symptoms.
4. Changes in Medication Regimen: Starting new medications or stopping existing ones without medical advice (especially mood stabilizers).
5. Seasonal Changes: Some people experience seasonal patterns in their mood disorders (e.g., Seasonal Affective Disorder).
6. Major Life Events/Changes: Both positive (like getting married) and negative events (like losing a job) can act as triggers.